To estimate the cost of infections associated with multidrug‐resistant organisms (s) during inpatient hospitalization in the United States.
2014 National Inpatient Sample.
Multivariable regression models assessed the incremental effect of s on the cost of hospitalization and hospital length of stay among patients with bacterial infections.
Data Sources/Study Setting
We retrospectively identified 6 385 258 inpatient stays for patients with bacterial infection.
The national incidence rate of inpatient stays with bacterial infection is 20.1 percent. At least 10.8 percent of such stays—and as many as 16.9 percent if we account for undercoded infections—show evidence of one or more s. ,, infection with another , and the presence of more than one are associated with $1718 (95% , $1609‐$1826), $4617 (95% , $4407‐$4827), $2302 (95% , $2044‐$2560), and $3570 (95% , $3019‐$4122) in additional costs per stay, respectively. The national cost of infections associated with s is at least $2.39 billion (95% , $2.25‐$2.52 billion) and as high as $3.38 billion (95% , $3.13‐$3.62 billion) if we account for undercoded infections.
Infections associated with s result in a substantial cost burden to the health care system.
Data Collection/Extraction Methods